GHK-CU - 100mg (Copper Peptide)

1. Copper Ion Activation

GHK-CU binds tightly to copper (II) ions, forming a biologically active complex. This bond acts as a cellular signaling molecule, triggering pathways that stimulate repair and protect cells from oxidative stress.It regulates key processes including:

• Collagen and elastin synthesis
• Glycosaminoglycan (GAG) and proteoglycan production
• Angiogenesis and oxygen transport
• Superoxide dismutase (SOD) activity, a crucial antioxidant enzyme

The copper-GHK complex enhances enzymatic reactions essential for cell renewal, extracellular-matrix formation, and skin rejuvenation.

2. Gene Expression Modulation

Studies demonstrate that GHK-CU resets gene expression toward a youthful state - activating hundreds of regenerative genes while suppressing those linked to inflammation and degeneration.It up-regulates:

• DNA repair genes
• Stem-cell proliferation pathways
• Antioxidant defense mechanisms

Simultaneously, it down-regulates genes associated with fibrosis, cancer progression, and chronic inflammation, contributing to a rebalanced cellular environment.

3. Wound Healing and Tissue Regeneration

GHK-CU promotes fibroblast migration, keratinocyte activation, and angiogenesis, accelerating tissue regeneration and scar remodeling. It assists in:

• Epithelial layer repair following injury
• Collagen organization in damaged tissue
• Increased vascularization, providing oxygen and nutrients to the repair site

These combined effects make it one of the most versatile healing peptides studied to date.

4. Anti-Inflammatory & Antioxidant Action

By balancing copper homeostasis and boosting SOD activity, GHK-CU reduces free-radical damage and inhibits pro-inflammatory cytokines such as TNF-α and IL-6.This antioxidant activity supports longevity studies, cellular protection, and skin anti-aging research.

• Skin regeneration and wound-healing models
• Anti-aging and collagen synthesis research
• Hair-follicle stimulation and dermal health
• Studies in oxidative stress reduction
• Cellular-protection and gene-expression research
• Post-surgical recovery and scar-healing studies

GHK-CU - 100 mg Lyophilised peptide powder

GHK-Cu (Copper Peptide) 100 mg — Research Dosage Guidance

Skin Rejuvenation • Wound Healing • Hair Growth • Anti-Aging Research

Reconstitution (Mixing)

• Add 3 ml Bacteriostatic Water to the vial
• Roll gently between palms (do not shake)
• Store reconstituted vial in the refrigerator (2–8 °C)

Concentration Calculation

100 mg ÷ 3 ml ≈ 33.3 mg/ml

Every 10 units (0.1 ml) ≈ 3.3 mg

Core Dosage Guidelines

For skin regeneration, tissue repair, hair stimulation, and longevity-focused research

Injectable skin therapy: 250 mcg – 3 mg per day

Topical / microneedling research: 0.5 – 3 mg per session

Do not exceed: 3 mg per day

⚠️ Higher daily exposure may increase angiogenesis and copper accumulation, particularly in long-term protocols or in subjects with impaired copper clearance.

Syringe Measurement Guide
Dose    Volume (ml)    Insulin Units
250 mcg    ≈ 0.007 ml    < 1 unit
500 mcg    ≈ 0.015 ml    1.5 units
1 mg    ≈ 0.03 ml    3 units
2 mg    ≈ 0.06 ml    6 units
3 mg (maximum)    ≈ 0.09 ml    9 units

Accuracy note: For doses under 0.1 ml, use 30–50 unit insulin syringes.

Targeted Research Protocols (Different Situations)
1.⁠ ⁠Skin Rejuvenation & Anti-Aging Research

• (Dermal thickness, elasticity, collagen renewal)
• Dose: 250–500 mcg
• Frequency: Once daily or every other day
• Route: Subcutaneous or intradermal
• Duration: 6–10 weeks
• Notes: Low-dose protocols often sufficient for cosmetic endpoints

2.⁠ ⁠Wound Healing & Tissue Repair

• (Post-procedure healing, scar modulation)
• Dose: 1–2 mg
• Frequency: Once daily
• Route: Local subcutaneous or intradermal near target area
• Duration: 4–8 weeks
• Notes: Supports angiogenesis and fibroblast activity

3.⁠ ⁠Hair Growth & Scalp Regeneration

• (Follicular support, vascular supply, hair density)
• Dose: 500 mcg – 1.5 mg
• Frequency: 3–5× weekly
• Route: Intradermal scalp administration 
• Duration: 8–12 weeks
• Notes: Avoid excessive daily dosing to limit vascular overgrowth

4.⁠ ⁠Intensive Skin Repair / Post-Laser or Microneedling Research

• (Barrier recovery, collagen induction)
• Dose: 1–3 mg
• Frequency: On treatment days only
• Route: Intradermal or topical application to treated area
• Duration: As per procedural protocol
• Notes: Do not exceed 3 mg/day

5.⁠ ⁠Longevity & Cellular Repair Research

• (Fibroblast signaling, tissue resilience)
• Dose: 250–500 mcg
• Frequency: 3–5× weekly
• Duration: 8–10 weeks
• Notes: Suitable for long-term, low-dose protocols

6.⁠ ⁠Maintenance / Long-Term Skin Support

• Dose: 250–500 mcg
• Frequency: Every other day or 2–3× weekly
• Duration: Ongoing after full cycle
• Notes: Minimizes copper load while maintaining benefits

Copper-Related Safety Considerations

Excessive or prolonged exposure above 3 mg/day, especially when combined with high-dose copper supplementation, may increase risk of copper accumulation.

Possible signs of copper overload include:

• Fatigue or nausea
• Metallic taste
• Elevated liver enzymes (AST/ALT)
• Neurological irritability or confusion
• Use caution in research models involving:
• Impaired liver function
• Copper metabolism disorders (e.g. Wilson-type models)

Cycle Duration

• Typical cycle: 4–10 weeks
• Maintenance: Lower doses (250–500 mcg) daily or every other day
• Repeat cycles: May be repeated with appropriate washout periods

Key Research Benefits

• Stimulates collagen and extracellular matrix renewal
• Enhances wound healing and tissue regeneration
• Supports hair follicle vascularization and growth
• Improves skin texture, elasticity, and repair capacity
• Activates regenerative and longevity-associated pathways

Important Notes

Always use sterile needles and alcohol swabs

Do not reuse or share needles

Store reconstituted vial at 2–8 °C

For research use only

GHK-Cu is a bioactive copper peptide that promotes angiogenesis, cellular repair, and collagen synthesis. Use caution or avoid in the following research contexts:

Active cancer or tumor-bearing models (angiogenic and proliferative signaling)

Wilson’s disease or copper-storage disorders (risk of copper accumulation)

Severe hepatic or renal impairment (reduced copper clearance)

Pregnancy or lactation models (no safety data available)

Severe skin barrier damage, open wounds, or active infection (potential copper irritation or unpredictable response)

The burning or blue hue effects of GHK-CU are local, concentration-related, and reversible. They occur from transient copper-ion reactions with skin proteins or microcapillaries and typically resolve within 24–72 hours after removal or dilution of the peptide.