Ipamorelin - 10 mg (Selective Growth Hormone Secretagogue)

1. Ghrelin-Receptor Stimulation (GHSR-1a)

Ipamorelin binds selectively to the ghrelin (growth hormone secretagogue) receptor, triggering the pituitary to release pulsatile bursts of GH. This receptor activation:

• Elevates circulating GH while keeping ACTH and cortisol unchanged
• Supports natural, rhythmic GH secretion
• Enhances IGF-1 production downstream in the liver and tissues
• Promotes cellular regeneration and anabolic signaling

This mechanism closely mimics physiological GH patterns, providing predictable and balanced activity.

2. Muscle Growth, Recovery & Tissue Repair

Research shows Ipamorelin contributes to:

• Myocyte growth and repair through GH/IGF-1 axis stimulation
• Enhanced protein synthesis and nitrogen retention
• Improved joint, tendon, and skin resilience
• Accelerated recovery following stress, injury, or exercise

These effects make it a valuable compound for musculoskeletal and regenerative-health studies.

3. Anti-Aging & Cellular Renewal

GH and IGF-1 elevation via Ipamorelin supports:

• Collagen and elastin synthesis for improved dermal structure
• Mitochondrial energy optimization
• Reduction of oxidative cellular damage
• Restoration of sleep quality and circadian rhythm (via GH-pulse modulation)

This peptide is frequently investigated in longevity and metabolic-repair research due to its selective, mild action profile.

4. Neuroprotective & Metabolic Effects

By influencing GH-linked pathways, Ipamorelin may also:

• Improve neurogenesis and cognitive resilience
• Regulate lipid metabolism and energy utilization
• Modulate immune balance through GH-mediated cellular signaling

These findings expand its value in neuroendocrine and age-related research models.

• Growth-hormone and IGF-1 axis studies
• Muscle repair and recovery models
• Anti-aging and regenerative-medicine exploration
• Metabolic and lipid-oxidation research
• Sleep, recovery, and neuroendocrine-function studies

Ipamorelin -10 mg Lyophilized Peptide Powder

Ipamorelin (10 mg) — Research Dosage Guidance

Growth Hormone Stimulation • Fat Loss • Recovery • Sleep Support

Reconstitution (Mixing)

• Add 2 ml Bacteriostatic Water to the vial
• Roll gently between palms (do not shake)
• Store reconstituted vial in the refrigerator (2–8 °C)

Concentration Calculation

10 mg ÷ 2 ml = 5 mg/ml

Every 10 insulin units (0.1 ml) = 0.5 mg (500 mcg)

Core Dosage Guidelines

For growth hormone stimulation, fat loss, recovery, and sleep-quality research

Standard research protocol: 200–500 mcg per injection

Frequency: 1–2× daily (morning and/or pre-sleep)

Advanced protocol: Up to 1 mg daily, split into 2 × 500 mcg doses

Administration: Subcutaneous (abdomen or thigh)

Injection sites: Rotate regularly

Syringe Measurement Guide
Dose    Volume    Insulin Units
200 mcg    0.04 ml    4 units
250 mcg    0.05 ml    5 units
500 mcg    0.10 ml    10 units
1 mg    0.20 ml    20 units

Reference: Every 10 units (0.1 ml) = 500 mcg Ipamorelin

Targeted Research Protocols (Different Situations)
1.⁠ ⁠Growth Hormone Support & Longevity Research

• (GH pulse amplification, healthy aging models)
• Dose: 200–300 mcg
• Frequency: Once daily
• Timing: Before sleep (fasted)
• Duration: 8–12 weeks
• Notes: Gentle GH stimulation with excellent tolerability

2.⁠ ⁠Fat Loss & Body-Composition Research

• (Lipolysis, lean-mass preservation)
• Dose: 300–500 mcg
• Frequency: 1–2× daily
• Timing: Morning (fasted) + pre-sleep
• Duration: 8–12 weeks
• Notes: Commonly stacked with CJC-1295 (no DAC)

3.⁠ ⁠Recovery & Muscle-Repair Research

• (Training stress, tissue recovery)
• Dose: 300–500 mcg
• Frequency: Once daily
• Timing: Post-training or pre-sleep
• Duration: 6–10 weeks
• Notes: Supports recovery without cortisol elevation

4.⁠ ⁠Sleep Quality & Night-Time Recovery

• (Sleep architecture, overnight GH release)
• Dose: 200–300 mcg
• Frequency: Once daily
• Timing: 30–60 minutes before sleep
• Duration: 6–8 weeks
• Notes: Lower doses often sufficient for sleep benefits

5.⁠ ⁠Advanced GH Optimization Protocol

• (Experienced research models)
• Dose: 500 mcg twice daily
• Total daily dose: 1 mg
• Duration: 8–12 weeks
• Notes: Split dosing reduces receptor fatigue

6.⁠ ⁠Maintenance / Long-Term GH Support

• Dose: 200–300 mcg
• Frequency: 3–5 days per week
• Duration: Ongoing after full cycle
• Notes: Maintains GH signaling with minimal exposure

Cycle Duration

• Typical cycle: 8–12 weeks
• Maintenance: 3–5 days per week
• Repeat cycles: May be repeated depending on research goals

Key Research Benefits

• Stimulates natural growth hormone release
• Does not significantly raise prolactin or cortisol
• Supports fat loss and lean-muscle preservation
• Enhances recovery, sleep quality, and skin health

Important Notes

Always use sterile needles and alcohol swabs

Do not reuse or share needles

Store reconstituted peptide at 2–8 °C

For research use only

Ipamorelin is a selective growth-hormone secretagogue that activates the GH/IGF-1 axis. Use caution or avoid in the following research contexts:

Active malignancy or tumor-bearing models (GH/IGF-1 signaling may enhance cell proliferation)

Pregnancy or lactation models (no safety data available)

Severe edema, heart failure, or kidney disease models (risk of fluid retention)

Uncontrolled diabetes or severe insulin resistance (monitor blood glucose closely)

Carpal-tunnel syndrome or neuropathy-prone models (monitor for temporary symptom worsening)

Pituitary disorders or abnormal GH-secretion models (may confound baseline GH activity)

Ipamorelin is a highly selective GH secretagogue researched for muscle recovery, sleep quality, and tissue repair without the cortisol spikes seen in older peptides. Side effects are generally mild and transient, most commonly temporary fatigue, mild fluid retention, or small itchy welts at the injection site. Proper dilution, slow administration, and site rotation minimize local irritation and ensure consistent, reliable outcomes in research settings.