Melanotan II - 10 mg (α-MSH Analog Peptide)

1. Melanocortin Receptor Activation -Pigmentation Response

Melanotan II binds to melanocortin-1 receptors (MC1R) located on skin melanocytes, stimulating melanin synthesis (melanogenesis). This process leads to:

• Increased production and dispersion of eumelanin (dark pigment)
• Enhanced UV protection through deeper pigmentation
• Support for studies on skin photoprotection and melanocortin signaling

This mechanism has made Melanotan II a central compound in research exploring melanin biology and photoadaptive responses.

2. Energy & Appetite Regulation

Melanotan II also influences melanocortin-3 and -4 receptors (MC3R, MC4R) in the hypothalamus, impacting energy homeostasis and appetite control. In research models, it:

• Modulates energy expenditure and lipid metabolism
• Decreases food intake via hypothalamic satiety signaling
• Supports studies in obesity, metabolic regulation, and caloric balance

These effects make it relevant for both dermatological and metabolic research fields.

3. Sexual Function & Neuroendocrine Research

Melanotan II is known to activate MC4R and MC3R in the central nervous system, which are linked to libido, arousal, and reproductive behavior. Studies have shown:

• Increased sexual arousal response in both male and female models
• Enhanced dopaminergic signaling related to motivation and reward
• Improved circulatory responses via nitric-oxide pathways

This makes it valuable in neuroendocrine and sexual-function research.

4. Mood & Stress Modulation

Because melanocortin receptors also modulate neuroinflammatory and stress pathways, Melanotan II has been observed to:

• Influence mood regulation and resilience
• Exhibit anti-inflammatory and antioxidant effects
• Support research on neuroimmune communication and mood balance

• Melanin biosynthesis and photoprotection research
• Metabolic-syndrome and energy-homeostasis studies
• Sexual-function and neuroendocrine investigations
• Appetite and hypothalamic-signaling research
• Stress, mood, and inflammation-pathway models

Melanotan II -10 mg Lyophilized Peptide Powder

Melanotan II — Research Dosage Guidance
Reconstitution (Mixing)

• Add 2 ml Bacteriostatic Water to the vial
• Roll gently between palms (do not shake)
• Store reconstituted vial in the refrigerator (2–8 °C)

Concentration Calculation

10 mg ÷ 2 ml = 5 mg/ml

Every 10 units (0.1 ml) = 0.5 mg (500 mcg)

Core Dosage Guidelines

For pigmentation, libido enhancement, and photoprotection research

Loading Phase

Dose: 250–500 mcg daily

Duration: Until desired pigmentation is achieved (typically 7–14 days)

Maintenance Phase

Dose: 250–500 mcg

Frequency: 2–3× per week

Administration: Subcutaneous (abdomen or thigh)
Optional timing: Evening dosing may reduce nausea or flushing

Syringe Measurement Guide
Dose    Volume (ml)    Insulin Units
250 mcg    0.05 ml    5 units
500 mcg    0.10 ml    10 units
1 mg    0.20 ml    20 units

Reference: Every 10 units (0.1 ml) = 500 mcg Melanotan II

Targeted Research Protocols (Different Situations)
1.⁠ ⁠Gradual Pigmentation / First-Time Research

• (Minimizing side effects, controlled melanin activation)
• Dose: 250 mcg
• Frequency: Once daily
• Duration: 10–14 days
• Maintenance: 250 mcg 2× weekly
• Notes: Preferred for sensitive research models

2.⁠ ⁠Rapid Pigmentation Development

• (Short-term melanin induction models)
• Dose: 500 mcg
• Frequency: Daily
• Duration: 7–10 days
• Maintenance: 500 mcg 2× weekly
• Notes: Monitor for flushing and nausea

3.⁠ ⁠Photoprotection & UV-Resilience Research

• (Skin resilience, UV response modulation)
• Dose: 250–500 mcg
• Frequency: 2–3× weekly
• Duration: 6–8 weeks
• Notes: Pigmentation may deepen gradually

4.⁠ ⁠Libido & Energy Pathway Research

• (α-MSH–related libido and mood effects)
• Dose: 250–500 mcg
• Frequency: 2–3× weekly
• Timing: Evening dosing preferred
• Duration: 4–6 weeks
• Notes: Lower doses often sufficient

5.⁠ ⁠Maintenance / Long-Term Tone Preservation

• Dose: 250 mcg
• Frequency: Once weekly
• Duration: As required after full cycle
• Notes: Helps sustain pigmentation with minimal exposure

Cycle Duration

• Initial pigmentation: ~1–2 weeks of daily dosing
• Maintenance: 2–3 injections per week
• Typical research cycle: 6–8 weeks
• Breaks: Recommended between cycles

Key Research Benefits

• Stimulates melanin production for gradual, natural pigmentation
• Supports UV protection and skin resilience
• May enhance libido and energy pathways
• Promotes mood and body-confidence signaling via α-MSH activation

Important Notes

Always use sterile needles and alcohol swabs

Do not reuse or share needles

Store reconstituted vial at 2–8 °C

For research use only

Possible dose-dependent effects include:

Temporary nausea or flushing

Darkening of freckles or moles

Melanotan II Who Should Use With Caution or Avoid (Research Contexts)

Melanotan II is a melanocortin peptide that stimulates melanin production and influences vascular and neurological signaling. Use caution or avoid in the following research contexts:

Personal or family history of melanoma or atypical/dysplastic moles (pigmentation changes may be amplified)

Pregnancy or lactation models (no safety data available)

Uncontrolled hypertension or cardiovascular disease models (transient blood-pressure or vascular effects possible)

Migraine or vascular-headache–sensitive models (vasodilation may exacerbate symptoms)

Active skin cancer or dermatologic oncology models (melanin stimulation may confound outcomes)

Severe hepatic or renal impairment (altered peptide clearance)

Melanotan II is a potent melanocortin receptor agonist supporting research into skin pigmentation, sexual function, and metabolic signaling. Most side effects -nausea, flushing, darkened freckles, or itchy welts -are dose-dependent and short-term. Proper dilution, gradual titration, hydration, and morning administration can reduce discomfort and improve tolerance in controlled laboratory conditions.