Selank - 10 mg (Heptapeptide Neuropeptide Analog)

1. GABA Receptor Modulation - Calm and Cognitive Stability

Selank enhances gamma-aminobutyric acid (GABA) neurotransmission by increasing GABA receptor binding and stabilizing inhibitory signaling in the central nervous system. This action promotes:

• Reduced anxiety and nervous system hyperactivity
• Improved emotional regulation and mental calmness
• Enhanced focus and memory retention under stress

Selank’s gentle, non-sedative modulation of GABA pathways makes it a unique compound in neurobehavioral and stress-response research.

2. Serotonin and Dopamine Regulation

Research indicates that Selank influences the serotonergic and dopaminergic systems, resulting in:

• Improved mood balance and motivation
• Enhanced mental clarity and alertness
• Reduced fatigue and cognitive fog associated with stress

By restoring neurotransmitter equilibrium, Selank supports studies focused on neurochemical balance and emotional homeostasis.

3. Immune and Anti-Inflammatory Effects

Selank exhibits immunomodulatory properties, believed to arise from its origin as a Tuftsin analog -a natural immunopeptide. It may:

• Enhance immune surveillance and cytokine regulation
• Reduce neuroinflammation linked to chronic stress
• Support systemic immune balance during fatigue or mental strain

This dual neuro-immune activity gives Selank particular relevance in psychoneuroimmunology research.

4. Cognitive Enhancement & Neuroprotection

Selank has been observed in research to:

• Improve short-term memory and learning capacity
• Support neural plasticity and synaptic stability
• Reduce oxidative and excitotoxic damage to neurons

Through these pathways, it offers broad potential in neuroprotection, focus enhancement, and cognitive-function studies.

• Neurotransmitter-regulation and GABA studies
• Stress-response and anxiety-model research
• Cognitive and memory-performance experiments
• Neuroprotection and oxidative-stress studies
• Immunomodulation and cytokine-balance research

Selank -10 mg Lyophilized Peptide Powder

Selank — Research Dosage Guidance
Reconstitution (Mixing)

• Add 3.0 ml Bacteriostatic Water
• Roll or swirl gently (do not shake)
• Protect from light
• Storage
• Lyophilized: Freeze at −20 °C
• After reconstitution: Refrigerate at 2–8 °C
• Do not refreeze once mixed

Concentration Calculation

10 mg ÷ 3.0 ml ≈ 3.33 mg/ml

1 insulin unit (0.01 ml) ≈ 33.3 mcg Selank

Core Dosage Guidelines (Subcutaneous)

For calm, focus, anxiety modulation, and cognitive-support research

Daily dosing range: 300–500 mcg

Frequency: Once daily

Administration: Subcutaneous (abdomen, thigh, or upper arm)

Titration Protocol
Weeks 1–2 (Start Phase)

Dose: 300 mcg daily

Volume: 0.09 ml

Insulin units: 9 units

Weeks 3–4 (Target Phase)

Dose: 500 mcg daily

Volume: 0.15 ml

Insulin units: 15 units

Accuracy note: For doses under 0.10 ml, use 30–50 unit insulin syringes.

Targeted Research Protocols (Different Situations)
1.⁠ ⁠Anxiety Reduction & Calm-State Research

• (Stress response, GABAergic modulation models)
• Dose: 300 mcg
• Frequency: Once daily
• Timing: Morning or early afternoon
• Duration: 3–4 weeks
• Notes: Lower doses often sufficient for anxiolytic effects

2.⁠ ⁠Focus & Cognitive Stability Research

• (Attention, mental clarity, executive function)
• Dose: 300–500 mcg
• Frequency: Once daily
• Timing: Morning
• Duration: 4 weeks
• Notes: Non-stimulating cognitive support

3.⁠ ⁠Stress-Adaptation & Emotional Regulation

• (HPA-axis balance, resilience studies)
• Dose: 500 mcg
• Frequency: Once daily
• Timing: Morning
• Duration: 4–6 weeks
• Notes: Often stacked in cognitive-support protocols

4.⁠ ⁠Post-Stress / Burnout Recovery Models

• (Mental fatigue, nervous-system recalibration)
• Dose: 300–500 mcg
• Frequency: Once daily
• Duration: 4 weeks
• Notes: Gradual titration recommended

5.⁠ ⁠Maintenance / Long-Term Support Research

• Dose: 300 mcg
• Frequency: 3–5 days per week
• Duration: Ongoing after a full cycle
• Notes: Helps maintain calm focus with minimal exposure

Cycle & Scheduling Options

Standard cycle: 4 weeks on / 4 weeks off

Alternate schedule: 5 days on / 2 days off weekly

Repeat cycles: May be repeated as needed depending on research goals

Protocol Overview

• Purpose: Calm, focus, cognitive support
• Daily range: 300–500 mcg
• Cycle: 4 weeks on, 4 weeks off
• Concentration: 3.0 ml → ~3.33 mg/ml
• Injection: Once daily, rotate sites
• Subcutaneous Injection Guide
• Clean vial and injection site with alcohol
• Draw dose and remove air bubbles
• Inject slowly at 90°
• Rotate abdomen, thighs, or upper arms
• Use a new sterile syringe each time

Important Notes

Always use sterile needles and alcohol swabs

Do not reuse or share needles

Store reconstituted peptide at 2–8 °C, away from light

For research purposes only

Selank Who Should Use With Caution or Avoid (Research Contexts)

Selank is an anxiolytic neuropeptide that modulates GABAergic signaling and emotional-regulation pathways. Use caution or avoid in the following research contexts:

Pregnancy or lactation models (no safety data available)

Severe depressive or psychotic models (may interfere with baseline mood or behavioral readouts)

Uncontrolled epilepsy or seizure-prone models (GABA modulation may alter seizure thresholds)

Concurrent use with chronic sedative or benzodiazepine protocols (potential for additive sedation)

Allergic rhinitis or sinus-sensitive models when using intranasal administration (temporary local irritation possible)

Selank is a neuropeptide studied for stress reduction, mental focus, and mood balance through gentle modulation of neurotransmitters and immune signaling. It is very well tolerated, with occasional mild drowsiness, nasal irritation, or small itchy welts as the most common observations. Most effects are dose-related, transient, and self-resolving, making Selank one of the safest peptides for neurocognitive research contexts.